|Magdalena Józefowicz-Korczyńska, Marcin Mazerant , Kamal Morshed, Izabela Olejniczak, Katarzyna Bojanowska-Poźniak|
Introduction. Human papilloma virus (HPV) has been
recognized as a major risk factor for carcinogenesis of head and
neck tumors. It is strongly linked to oropharyngeal carcinomas.
The role of HPV infection in the etiology of laryngeal carcinoma
is still not clear.
Aim. The aim of the study was to evaluate the prevalence of
HPV and its types in laryngeal cancer patients and assess the
relationship between HPV infection and the epidemiological,
clinical and histological characteristics of the tumour in the
Material and methods. The retrospective data in 100 patients
with laryngeal cancer after surgical treatment were reviewed and
statistically analysed. Only T3 and T4 cases, without a history
of previous radio- or chemotherapy were included. The viral
genotype was detected in archived paraffin block specimens by
INNO-LiPA HPV Genotyping Extra (Innogenetics).
Results. The presence of 23% HPV positive tumors was
confirmed. The HPV virus was significantly more frequent in
subjects smoking less than 10 cigarettes daily (p<0.05) and
drinking strong alcohol drinks only occasionally (p=0.019).
In patients with well-differentiated larynx tumors, HPV was
not found (p=005). There was no correlation between HPV
presence in laryngeal cancer tissues and patient’s data such as
sex, age, occupation, dwelling place or tumor stage.
Conclusions. HPV was found to be present in almost one fourth
of the studied patients with laryngeal carcinoma. HPV infection
was more frequent in patients without typical risk factors.
keywords: HPV, rak krtani, epidemiologia, HPV, laryngeal cancer, epidemiology
pages: from 155 to 161
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