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  Patronage of the Polish Society of Audiology and Phoniatrics

vol 12. no 2. June 2013  

 Review articles
Pharmacological methods of hearing protection in acoustic trauma – a review of animal studies and clinical trials
Anna Wolniakowska, Mariola Śliwińska-Kowalska

Given the prevalence of exposure to noise, both occupational
and environmental, the difficulties in noise elimination and the
limited success of hearing protection against noise by technical
measures, the development of pharmacological interventions
for the prevention of hearing loss seems to be a priority. It is
essential to ensure that the applied formulations are characterized
by high bioavailability and their doses are safe.
The paper discusses the attempted pharmacological interventions
against acute and chronic acoustic trauma by the application
of drugs registered for use in humans (N-acetylcysteine,
salicylates), compounds that are natural components of food
(D-methionine - an amino acid commonly found in yogurt and
cheese) and dietary supplements (magnesium salts, vitamins).
The results of tests obtained in animal models and in humans
have been reported.
It appears that some of the compounds (D-methionine) are
likely to be extensively implemented in the prevention of acute
acoustic trauma in the near future.

keywords: uszkodzenie słuchu, interwencja farmakologiczna, D-metionina, hearing loss, pharmacological intervention,D‑methionine

pages: from 72 to 75

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