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  Patronage of the Polish Society of Audiology and Phoniatrics

vol 12. no 1. March 2013  

 Review articles
Streptococcus pneumoniae carriage and pneumococcal disease
Izabela Korona-Głowniak, Artur Niedzielski

Streptococcus pneumoniae is a major cause of morbidity
and mortality worldwide. The virulence of this bacterium is
dependent on numerous virulence factors, but polysaccharide
capsule is the most important, and differences in the
composition of the capsule are the basis for the classification
of pneumococci into more than 90 serotypes. Nasopharyngeal
carriage of pneumococcus precedes disease and is the source of
pneumococcal spread between people. Although the relationship
between carriage and disease is not well understood, evidences
suggest that local or invasive infection is caused by serotypes
that bind to the epithelial surface of the respiratory tract.
Natural immunity to the pneumococcus was largely mediated by
antibodies to the polysaccharide capsule. However, last studies
of human carriage have implicated a range of surface protein
antigens in protection against both nasopharyngeal colonization
and invasive disease.

keywords: Streptococcus pneumoniae, nosicielstwo, choroba pneumokokowa, otoczka jako główny czynnik wirulencji, Streptococcus pneumoniae, carriage, capsule as an important virulence factors, pneumococcal disease

pages: from 1 to 7

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