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  Patronage of the Polish Society of Audiology and Phoniatrics

vol 11. no 3. September 2012  

 Original articles
The clinicopathological significance of the expression of CCR3 gene and protein in laryngeal squamous cell carcinoma
Katarzyna Starska, Iwona Lewy-Trenda, Paweł Papież, Jan Woś, Ewa Forma, Magdalena Bryś

Introduction. CCR3 (CD193), C-C chemokine receptor
type 3 is a receptor that is highly expressed in eosinophils and
basophils, and is also detected in Th cells, as well as in airway
epithelial cells. Nevertheless, little is known about the function
of chemokine receptors in the development and progression
of laryngeal cell carcinoma.
Aim. The aim of this study was to analyze the expression of
CCR3 in peripheral blood mononuclear cells, on the gene and
protein level, and to find links with clinical and morphological
characteristics (pT, depth and type of invasion) in the carcinoma
of the larynx.
Material and methods. The analysis included a group of 71
patients with confirmed laryngeal carcinoma. pTNM and TFG
classification criteria were applied for the pathological assessment.
The expression of markers in the blood cells of patients
was assessed using the RT-PCR and Western blot techniques.
Results. Increased expression of CCR3 in peripheral blood
mononuclear cells (PBMC) was an indicator of advanced tumours
evaluated on the basis of the characteristics of pT (pT3-4).
Tumours at the highest stages of progression identified by TFG
criteria (TFG3-4) were associated with higher expression of
CCR3 in PBMC of the studied group of patients. In laryngeal
carcinomas characterized by deep invasion with cartilage infiltration,
the CCR3 expression was shown to be higher, as well.
Conclusions. The study proves the importance of the CCR3
expression in T lymphocytes as an indicator of advanced changes
and progression in patients with laryngeal carcinoma.
Key words: laryngeal carcinoma, chemokine receptor CCR3,
peripheral blood mononuclear cells

keywords: rak krtani, receptor dla chemokin CCR3,jednojądrzaste komórki krwi

pages: from 101 to 108

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