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  Authority of Polish Society of Allergology

vol 8. no 1. March 2003  

 Original articles
Serum concentration of sICAM-1 in atopic allergy patients
Tomasz Pitsch, Barbara Rogala

Katedra i Klinika Chorób Wewnętrznych, Alergologii i Immunologii Klinicznej w Zabrzu, Śląskiej Akademii Medycznej w Katowicach, ul. 3 Maja 13/15, 41-800 Zabrze

Introduction. Increased levels of circulating form of intercellular adhesion molecule-1 (sICAM-1) in serum and other body fluids in inflammatory disorders were observed.
Aim of study. (I) to compare serum concentrations of sICAM-1 in atopic asthma, seasonal allergic rhinitis and atopic dermatitis, (II) to compare serum sICAM-1 and IgE levels.
Material and methods. 27 patients with episodic and mild asthma – AO group; 13 with seasonal allergic rhinitis – ANN group, 15 with atopic dermatitis – AEDS group, 8 healthy allergic rhinitis patients’ family members – R group and 15 healthy volunteers (age: 18-44; mean age: 29.4) – OZ group. Serum levels of sICAM-1, IgE and some air-borne allergen specific IgE were studied by means of ELISA method.
Results. Serum sICAM-1 levels were higher in groups AO, ANN, AEDS and R in comparison with OZ group. No differences between sICAM-1 levels in A, AEDS, ANN and R groups were found. There was a significant correlation only between sICAM-1 and Dermatophagoides pteronyssimus allergen specific IgE in ANN group and between sICAM-1 and dog dander allergen specific IgE in AO group.
Conclusions. Increased serum sICAM-1 levels in patients suffering from atopic diseases can be observed. There is no difference in serum sICAM-1 concentrations between different diseases.
Alergia Astma Immunologia, 2003, 8(1), 39-44

keywords: cząsteczki adhezyjne, ICAM-1, sICAM-1, choroby atopowe, astma, alergiczny nieżyt nosa, atopowe zapalenie skóry, adhesion molecules, ICAM-1, sICAM-1, atopic diseases, asthma, allergic rhinitis, atopic dermatitis

pages: from 39 to 44

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