|Andrzej Mariusz Fal, Marta Rosiek, Jan Biegus, Józef Małolepszy|
Katedra i Klinika Chorób Wewnętrznych i Alergologii Akademii Medycznej, ul. Traugutta 57/59, 50-417 Wrocław
This paper reviews current knowledge on the genetics and biochemistry of eotaxin and its receptor – CCR3 as well as molecular mechanisms of their impact on eosinophils. Further, the role of eotaxin in the pathomechanism of eosinophil-influx-related diseases is discussed with the emphasis on bronchial asthma. Briefly: in concert with IL-5, eotaxin increases liberation of mature eosinophils from the bone marrow, promoting both blood and peripheral tissue eosinophilia. Eotaxin is the most effective in vivo chemoattractant for eosinophils and regulates eosinophil migration to peripheral tissue against its gradient. Further, it seems to delay eosinophil apoptosis outside blood vessels, at the same time activating the cells by binding to cell surface receptor and eventually leading to eosinophil degranulation. Taken together, based on the properties and functions, in the future eotaxin or its receptor may become a reasonable target in the treatment of the diseases with tissue eosinophilia.
Alergia Astma Immunologia, 2003, 8(1), 19-24
keywords: eotaksyna, gen eotaksyny, receptor CCR3, zapalenie alergiczne, eotaxin, eotaxin gene, CCR3 receptor, allergic inflammation
pages: from 19 to 24
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