wersja polska  
Mediton - Publishing House
Start page  Journals  Books  Conferences  News  Mediton  Contact   
   Journals
print this
   Allergy Asthma Immunology - archive  

Allergy Asthma Immunology
     Archive
     Editorial staff
     Editorial board
     For authors
     Subscription
Otorhinolaryngology
Allergology Review



 Search in articles:
  Authority of Polish Society of Allergology




vol 8. no 1. March 2003  
 TABLE OF CONTENT

 Clinical immunology
Eotoxin and its role in the pathophysiology of eosinophilic inflammation
Andrzej Mariusz Fal, Marta Rosiek, Jan Biegus, Józef Małolepszy

Katedra i Klinika Chorób Wewnętrznych i Alergologii Akademii Medycznej, ul. Traugutta 57/59, 50-417 Wrocław


This paper reviews current knowledge on the genetics and biochemistry of eotaxin and its receptor – CCR3 as well as molecular mechanisms of their impact on eosinophils. Further, the role of eotaxin in the pathomechanism of eosinophil-influx-related diseases is discussed with the emphasis on bronchial asthma. Briefly: in concert with IL-5, eotaxin increases liberation of mature eosinophils from the bone marrow, promoting both blood and peripheral tissue eosinophilia. Eotaxin is the most effective in vivo chemoattractant for eosinophils and regulates eosinophil migration to peripheral tissue against its gradient. Further, it seems to delay eosinophil apoptosis outside blood vessels, at the same time activating the cells by binding to cell surface receptor and eventually leading to eosinophil degranulation. Taken together, based on the properties and functions, in the future eotaxin or its receptor may become a reasonable target in the treatment of the diseases with tissue eosinophilia.
Alergia Astma Immunologia, 2003, 8(1), 19-24


keywords: eotaksyna, gen eotaksyny, receptor CCR3, zapalenie alergiczne, eotaxin, eotaxin gene, CCR3 receptor, allergic inflammation

pages: from 19 to 24



estimated time of download (82 kB)
broadband speed:561282565121024[kbps]
time:176422[sec]


You need to have Adobe Acrobat Reader to view the PDF file. It's free. If you don't have the Adobe Acrobat Reader plugin yet, you can get it HERE.


Start page | Journals | Books | Conferences | News | Mediton | Contact

Copyright © 1996-2020 Mediton Publishing House | All rights reserved.