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  Authority of Polish Society of Allergology

vol 8. no 1. March 2003  

 Bronchial asthma
Asthma due to glutaraldehyde
Waldemar Lutz1, Cezary Pałczyński2

1)Zakład Immunotoksykologii, Instytut Medycyny Pracy im. Nofera w Łodzi, ul. Św. Teresy od Dzieciątka Jezus 8, 90-950 Łódź
2)Klinika Chorób Zawodowych, Ośrodek Alergii Zawodowej i Środowiskowej, Instytut Medycyny Pracy im. Nofera w Łodzi, ul. Św.

Glutaraldehyde (GA) is commonly used as a disinfectant and a steriliser in the health care settings. The principal health effects of GA are irritation of the skin, eye and respiratory tract, skin sensitization and occupational asthma. Over the last several years the incidence of occupational respiratory allergies from GA exposure has increased in the US, European Union as well as Poland. GA has been regarded by several authors as the main cause of occupational asthma among medical personnel. GA is used for cold sterilization of medical instruments and endoscopic equipment as well as hardening agent in x-ray film processing.Thus, the highest risk group are workers at the endoscopy and radiology units. Significant GA exposure can also be encounterd in agriculture, fishery and chemical industry. Allergic asthma related to hypersensitivity to GA can develop in workers exposed to concentrations lower than the occupational exposure limits value. It remains to be seen whether its mechanism is IgE-dependent. The pathogenesis of GA-induced airway sensitisation is associated mainly with intracellular matabolism of GA and chemical reactions between glutaral and lysin-rich proteins leading to generation of important antigen determinants. In sensitized subjects the asthmatic reaction is either biphasic or late isolated, commonly accompanied with rhinitis symptoms. The diagnostics of airway allergy to GA is based mainly on standardized specific inhalatory challenge tests.
Alergia Astma Immunologia, 2003, 8(1), 9-18

keywords: aldehyd glutarowy, astma zawodowa, patogeneza, glutaraldehyde, occupational asthma, pathogenesis

pages: from 9 to 18

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