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  Authority of Polish Society of Allergology

vol 8. no 1. March 2003  

 Diagnostics and treatment of allergy
Immunostymulatory sequences of bacterial DNA (CpG DNA) - connection with allergic diseases
Maciej Chałubiński, Marek L. Kowalski

Katedra i Zakład Immunologii Klinicznej Uniwersytetu Medycznego w Łodzi, ul. Pomorska 251, 92-213 Łódź

The human and mammalian immune system has the ability to recognize the presence of bacterial DNA on the basis of recognition of CpG motifs (unmethylated cytidine-guanosine dinucleotides) within a particular base context. Several raports have shown that CpG motifs are both potent inducers of Th1-response that eliminates intracellular pathogenes and inhibitors of eosinophils and mast cells activation as well as IgE production, thus inhibiting Th2 type immune response characteristic for the allergic inflammation. It has been postulated that CpG DNA establishes Th1/Th2 balance, supporting the concept that the injection of allergen conjugated with appropriate CpG motifs may provide a novel immunotherapeutic approach for the treatment of allergic disorders.
Alergia Astma Immunologia, 2003, 8(1), 1-7

keywords: alergia, motywy CpG, odpowiedź immunologiczna Th1/Th2, allergy, CpG motifs, Th1/Th2 response

pages: from 1 to 7

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