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  Authority of Polish Society of Allergology

vol 7. no 4. December 2002  

 Original articles
Three months treatment with formoterol in mild asthma
Anna Dagmara Bareła, Jolanta Wrońska, A. Safianowska, Ryszarda Chazan

Klinika Chorób Wewnętrznych, Pneumonologii i Alergologii, Samodzielny Publiczny Centralny Szpital Kliniczny Akademii Medycznej, ul. Banacha 1a, 02-097 Warszawa

Introduction. Formoterol is a long-acting b2-agonist, used in asthma management.
Aim of study. The aim of this study was to assess a three month period of treatment with formoterol, its influence on lung function, tolerability and side effects.
Material and methods. Eighteen patients with mild asthma, 11 women and 7 men, mean age 27.5, were recruited. Formoterol was given in a dose of 12 µg twice a day, in inhalation capsules. The patients underwent baseline studies as follows: spirometric parameters (FEV1, FVC, FEV1/FVC), 12-lead ECG, blood tests including aminotranspherase, plasma potassium and glucose level and blood cell count were done. After three months of treatment spirometry was repeated. Evaluation of the ECG, plasma potassium and glucose level was carried out before taking formoterol and 1 hour afterwards.
Results. FVC after 3 month treatment increased significantly in all subjects (p = 0.003). FEV1 and FEV1/FVC changes did not reach significant level. There were no significant changes in the ECG after 3 month observation, neither any changes in the ECG performed 1 hour after administering the drug. Plasma potassium and glucose level did not change significantly after 3 months. However, the fall of potassium 1 hour after taking formoterol was significant (p=0.0001), so was the increase of the glucose level (p=0.01). All subjects reported decreased use of rescue medication, three had tremor after taking the drug.
Conclusion. Formoterol proved to be well-tolerated and helpful in maintenance treatment of mild asthma. There is no evidence of dangerous adverse effects of formoterol during three month treatment. Alergia Astma Immunologia, 2002, 7(4), 223-227

keywords: astma, formoterol, b2-mimetyki dlugo dzialajace, asthma, formoterol, long-acting b2-agonists

pages: from 223 to 227

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