|Barbara Rymarczyk, Zenon Brzoza, Alicja Grzanka, Barbara Rogala|
Katedra i Klinika Chorób Wewnętrznych, Alergologii i Immunologii Klinicznej Śląskiej Akademii Medycznej, ul. 3 Maja 13/15, 41-800 Zabrze
Introduction.: The genetic background of atopic diseases is an up-to-date research problem. The unequivocal analysis of this phenomenon is difficult as the atopy phenotype differs remarkably.
Aim of study. The aim of the study was to analyze the incidence of atopic features in parents of asthmatic offspring.
Material and methods. 18 patients with bronchial asthma and allergic rhinitis (11 patients with seasonal and 7 patients with perrenial rhinitis) were enrolled into the study. All subjects underwent physical examination and the medical history was obtained. In all study participants, the skin prick tests and the serum concentration of total IgE, allergen specific IgE, IL-4, sIL-4 and IL-5 were studied.
Results. All the asthmatic patients showed elevated allergen specific IgE serum levels (>0,7 IU/ml). Total IgE serum levels were significantly higher in both examined groups of offspring composed with their parents. The incidence of atopic features based on elevated total and allergen specific IgE serum levels was found in 8% of parents (2 mothers and 1 father).
There were no statistically significant differences in IL-4 serum concentrations in the offspring, and parents, or between both atopic groups. sIL-4R serum concentrations were statistically higher (p=0,04) in the parents group than in their asthmatic offspring. Serum levels of IL-5 were higher in the asthmatic subject than in their parents (p=0,01).
Conclusions. The low expression of atopy features in parents may be due to a recessive trait of inheritance and influence of the environment on the occurrence of atopic phenotype.
Alergia Astma Immunologia, 2002, 7(3), 160-163
keywords: atopia, astma oskrzelowa, dziedziczenie atopii, atopy, asthma, inheritance of atopy
pages: from 160 to 163
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