|Barbara Rogala, Mariusz Szczerbowski*, Sławomir Żegleń, Alicja Grzanka|
Katedra i Klinika Chorób Wewnętrznych, Alergologii i Immunologii Klinicznej Śląskiej Akademii Medycznej w Katowicach, ul. 3 Maja 13/15, 41-800 Zabrze
*Wojewódzki Szpital Chorób Płuc i Gruxlicy, ul. K. Miarki 14, 40-082 Kup k. Opola
Introduction. Selenium is a compound of numerous enzymes important in several immune processes. However, the literature data concerning the role of selenium deficiency in asthmatic inflammation are scarce and equivocal.
Aim of study. The aim of the study was to evaluate the plasma and whole blood selenium concentrations in asthmatic patients in relation to other ions, including sodium, potassium and magnesium.
Material and methods. 57 asthmatic patients (mean age 36.4 years) diagnosed according to the Global Strategy for Asthma Management and Prevention guidelines and 15 healthy controls were included. Following inclusion criteria were involved: positive skin prick test at least against two standard allergens and total IgE level > 100 IU/mL. Fluorometric assay of selenium concentration was performed. Sodium and potassium levels were estimated using ion selective method, and magnesium concentration was assayed by the colorimeter.
Results. No differences in selenium plasma and whole blood concentrations between studied and control group, as well as in sodium, potassium and magnesium concentrations were found. Neither, any significant relationship between studied ions was observed.
Conclusions. The results of the study do not support a role of selenium in the pathogenesis of asthma.
Alergia Astma Immunologia, 2002, 7(3), 141-145
keywords: astma oskrzelowa, selen, sód, potas, magnez, bronchial asthma, selenium, sodium, potassium, magnesium
pages: from 147 to 150
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