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  Authority of Polish Society of Allergology

vol 7. no 3. September 2002  

 Clinical immunology
Comparison of immune response in sarcoidosis and tuberculosis
Tadeusz M. Zielonka

Instytut Gru¼licy i Chorób P³uc w Warszawie, ul. P³ocka 26, 01-138 Warszawa

Clinical and radiological features of sarcoidosis and tuberculosis (TB) may look similar, thereby rendering diagnosis more difficult. Immune system performs a key role in pathogenesis of both diseases. The paper presents the disease typical humoral and cellular immunological reactions. Immunological response, both in the case of TB and sarcoidosis is based on production of many mediators. The paper presents respective cytokines with the most relevant role in pathogenesis of both diseases. Certain immunological phenomena in both TB and sarcoidosis are quite similar, wheareas some differ significantly. Similarities suggested the same etiology while differences are more and more often used in differential diagnosis. In spite of many years of research controversies in approaching similarities and differences between TB and sarcoidosis have not been resolved yet. Participation of mycobacteria in pathogenesis of sarcoidosis has yet to be confirmed or excluded. Better understanding of immunopathogenesis of these diseases is likely to facilitate quick differential diagnosis in the future.
Alergia Astma Immunologia, 2002, 7(3), 141-145

keywords: sarkoidoza, gru¼lica, patogeneza, immunologiczna odpowied¼, sarcoidosis, tuberculosis, pathogenesis, immunological response

pages: from 141 to 145

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