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Allergology Review

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  Authority of Polish Society of Allergology

vol 7. no 2. June 2002  

 Original articles
The conductivity of potassium ion channels in asthma patients at rest and after b-adrenergic and theophylline stimulation
Antonina Gawlik, Maryla Krasnowska, Andrzej Teisseyre*, Wacław Kopeć**, Sławomir Zmonarski**

Klinika Chorób Wewnętrznych i Alergologii, ul. Traugutta 57/59, 50-417 Wrocław
*Katedra i Zakład Biofizyki AM, ul. Chałubińskiego 10, 50-417 Wrocław
**Katedra i Klinika Nefrologii AM, ul. Traugutta 57/59, 50-417 Wrocław

Background: Ion channels, as the protein structures controlling ion exchange across cell membranes, constitute an important part of cellular signaling processes. The voltage operated potassium channels Kv1.3 within the membranes of lymphocyte T take part in physiological reactions in these cells. The measure of their activity is potassium conductivity (gK) that can be modified by various factors, including disease states.
Aims and methods: This study was designed to evaluate integrated potassium conductivity in lymphocytes T with the „patch-clamp” in a „whole-cell” type assay. The study included 42 healthy subjects and 72 asthmatic patients.
Results: The values of potassium conductivity did not significantly differ between the two groups. Further, the modulation of Kv channel activity was investigated in type T lymphocytes in the course of b-adrenergic stimulation with isoprenaline and with intracellularly introduced theophylline.
Conclusions: In both cases, the results of gK were not found to differ significantly from those of the controls.
Alergia Astma Immunologia, 2002, 8(2), 115-119

keywords: astma, kanały potasowe, przewodnictwo, asthma, potassium channels, conductivity

pages: from 115 to 119

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