|Ziemowit Ziętkowski, Anna Bodzenta-Łukaszyk, Marian Tomasik*, Jakub Giergiel**|
Klinika Alergologii i Chorób Wewnętrznych AM, ul. Skłodowskiej 24a, 15-276 Białystok
*Zakład Chemii Fizycznej AM w Białymstoku
**AstraZeneca Sp. z o.o.
Aims: The study was aimed to determine the role of nitric oxide and adhesion molecules (sE-selectin and sP-selectin) in the pathogenesis of EIB.
Methods: In total 30 patients were included (16 asthmatics with EIB, 8 asthmatics without EIB and 6 healthy volunteers). In all subjects a non-specific bronchial provocation test with histamine and exercise test using a bicycle ergometer were performed. The study parameters were measured before and then 15 and 60 min. after the exercise test.
Results: In the group of patients with EIB the NO concentration was significantly increased 15 min. after the test as compared to pre-test level, and returned to the norm 60 min. after the test was done. sE-selectin concentration also increased significantly 15 min. after performing the test, and remained unchanged on the 60th min. of observation, whereas sP-selectin concentration was raised 15 min. and returned to normal 60 min. after the exercise test was done. In neither astmatics without EIB nor healthy volunteers group changes of this kind were observed.
Conclusions: The results of the study suggest that the changes in concentrations of NO, sE-selectin and sP-selectin are connected to the mechanisms of exercise-induced bronchoconstriction.
Alergia Astma Immunologia, 2002, 8(2), 110-114
keywords: powysiłkowy skurcz oskrzeli, tlenek azotu, sE?selektyna, sP-selektyna, exercise-induced bronchoconstriction, nitric oxide, sE?selectin, sP-selectin
pages: from 110 to 114
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