Katedra Alergologii i Immunologii, Uniwersytetu Karola w Pilźnie, Alej Svobody 80, 304 60 Plzen, Czech Republic
Translated by Radosław Gawlik
The chronic inflammatory reaction in the bronchial mucosa in patients with chronic obstructive pulmonary disease (COPD) and chronic bronchitis is controlled by complex set of interacting cytokines. Unlike it is in case of bronchial asthma, factors that initiate and sustain the inflammatory changes in the airways of COPD and chronic bronchitis patients are little known. The latest evidence demonstrated that it is necessary to change our understanding of the relevant role of the cytokines released by Th1. The inflammatory cells in bronchial mucosa include macrophages beside of neutrophils, lymphocytes T, and eosinophils. The migration of macrophages is regulated not only by IL-8 but also numerous other chemokins. The chronic inflammatory processes are sustained by pro-inflammatory cytokines: IL-6, TNF?a and the remarkably fibrinogennic TGB-b. It appears that cigarette smoking, as the most relevant factor in the progression of COPD and chronic bronchitis, affects the spectrum and the concentrations of the cytokines released in the airways.
Alergia Astma Immunologia, 2002, 8(2), 91-99
keywords: przewlekła obturacyjna choroba płuc, przewlekłe zapalenie oskrzeli, cytokiny, chronic obstructive pulmonary disease, chronic bronchitis, cytokines
pages: from 91 to 99
|estimated time of download (165 kB)|