|Joanna Tomaszewicz 1/, Alicja Rączka 2/, Elżbieta Łuczak 1|
Recent years have shown that tobacco can play the role of allergen, due to its ability to induce specific IgE in serum. The aim of the study was to evaluate the prevalence of sensitization to tobacco in patients suffering from asthma, and allergic rhinitis comparing with patients with COPD and healthy controls.
The study was carried out in 100 subjects divided into 2 groups: I group (n = 70) atopic adults, 34 patients with atopic asthma and 46 patients with seasonal or perennial rhinitis, II group (n = 30) nonatopic adults, 20 patients with COPD and 10 healthy controls.
Skin prick tests and total IgE and specific IgE (sIgE) to tobacco leaf using fluoroimmunoenzymatic method were peformed on all patients. Among all patients passive and active smoking, tolerance to tobacco smoke and other sensitization were analyzed.
In group I in 12 subjects (17%) positive sIgE to tobacco in serum occured between first and third class. Sensitization to tobacco in examined group occured more frequently in asthma than in rhinitis patients. In group II (nonatopic adults) negative sIgE to tobacco was observed in all subjects.
Patients sensitizated to tobacco were characterized with worse tolerance for tobacco smoke while the exposure to smoking was comparable in both sensitizated and non-sensitizated groups.
Alergia Astma Immunologia, 2002, 7(1), 55-60
keywords: swoiste IgE, tytoń, astma, POChP, nieżyt nosa, specific IgE, tobacco, asthma, rhinitis, COPD
pages: from 55 to 60
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