|Sławomir Żegleń, Barbara Rogala, Tomasz Zbraniborski |
The importance of molecules belonging to TNF (tumor necrosis factor)/NGF (nerve growth factor) receptor superfamily in the pathophysiology of atopic disorders is still unclear. The decrease of soluble Fas (sFas/sCD95) concentration - interacting basic signals controlling cell death activation - associated with inhibition of apoptosis processes in atopic constitution is postulated.
The aim of the study was to evaluate the sFas concentration in respiratory atopic disorders and in atopic dermatitis.
The study included 56 atopic subjects: 21 patients with mild atopic bronchial asthma, 20 patients with seasonal rhinitis and 15 with mild atopic dermatitis. Control group consisted of 17 healthy donors. The enzyme immunoassay was used for quantitative determination of soluble Fas in human plasma and enzyme fluoroimmunoassay set for quantitative determination of total and specific IgE.
There was no difference in sFas concentration between the control group and asthmatics, patients with seasonal rhinitis or subjects with atopic dermatitis (median values - respectively: 9000 pg/mL vs 9000 pg/mL or 9100 pg/mL or 8800; p>0.05). No significant relationship between sFas and specific or total IgE was observed.
sFas molecule should not be considered as a marker of atopic diathesis and as a distinctive factor of respiratory atopic disorders or atopic dermatitis.
Alergia Astma Immunologia, 2002, 7(1), 49-54
keywords: choroby atopowe, sFas, apoptoza, atopic disordes, sFas, apoptosis
pages: from 49 to 54
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