|Iwona Mozer-Lisewska 1/, Wojciech Służewski 1/, Magdalena Filipowicz 1/, |
The mechanism of action of interferon alpha (IFN-a), currently the most commonly used drug in the treatment of chronic HBV infection in children, is not fully elucidated, although it is believed that its effect is mainly immunoregulatory. The aim of this study was to determine in treated children the changes in total lymphocytes and their subpopulations. The study included 16 children; 3 MU of INF-a was administered 3 times a week, for 20 weeks. Lymphocyte subpopulations were assessed using flow cytometry.
The total number of lymphocytes, CD3+ T cells, and CD19+ B cells rose significantly during and at the end of IFN-a treatment compared to the values at the onset of therapy. CD4/CD8 cell ratio as well as NK cells have shown slight fall at the end of treatment, while activated cells (CD69+) rose modestly after termination of therapy. Children showing low values of AlAT activity had as a rule, higher counts of lymphocytes and their subsets than those with high values of the enzyme, albeit without significance.
The results of the study suggests that the evaluation of lymphocyte immunophenotype may be of value in monitoring IFN-a therapy of children with chronic hepatitis B.
Alergia Astma Immunologia, 2002, 7(1), 44-48
keywords: zakażenia HBV, dzieci, interferon-a, immuno-fenotyp, limfocyty, HBV infection, children, interferon alpha, immuno-phenotype, lymphocytes
pages: from 44 to 48
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