wersja polska  
Mediton - Publishing House
Start page  Journals  Books  Conferences  News  Mediton  Contact   
print this
   Allergy Asthma Immunology - archive  

Allergy Asthma Immunology
     Editorial staff
     Editorial board
     For authors
Allergology Review

 Search in articles:
  Authority of Polish Society of Allergology

vol 6. no 3. September 2001  

 Diagnostics and treatment of allergy
The influence of antihistamines on the cardiovascular system
Jerzy Szewczyk, Jerzy Kruszewski

The present study describes clinically significant problem of the adverse reactions to antihistamines, resulting from their influence on the circulatory system. It has been emphasized that the problem concerns the second generation antihistamines only and derives from their ability to block potassium channels IKr and IK1 of myocytes as well as from the interaction with other drugs on the metabolic pathways of CYP4A isoenzyme of cytochrome P450. These effects may occur as life-threatening arrythmias ("torsade de pointes") and they prompted the withdrawal of terfenadine and astemizol from the market.
Alergia Astma Immunologia, 2001, 6(3), 135-141

keywords: leki przeciwhistaminowe, działania niepożądane, kanały potasowe, antihistamines, adverse reactions, potassium channels

pages: from 135 to 141

estimated time of download (79 kB)
broadband speed:561282565121024[kbps]

You need to have Adobe Acrobat Reader to view the PDF file. It's free. If you don't have the Adobe Acrobat Reader plugin yet, you can get it HERE.

Start page | Journals | Books | Conferences | News | Mediton | Contact

Copyright © 1996-2020 Mediton Publishing House | All rights reserved.