|Jerzy Szewczyk, Jerzy Kruszewski|
The present study describes clinically significant problem of the adverse reactions to antihistamines, resulting from their influence on the circulatory system. It has been emphasized that the problem concerns the second generation antihistamines only and derives from their ability to block potassium channels IKr and IK1 of myocytes as well as from the interaction with other drugs on the metabolic pathways of CYP4A isoenzyme of cytochrome P450. These effects may occur as life-threatening arrythmias ("torsade de pointes") and they prompted the withdrawal of terfenadine and astemizol from the market.
Alergia Astma Immunologia, 2001, 6(3), 135-141
keywords: leki przeciwhistaminowe, działania niepożądane, kanały potasowe, antihistamines, adverse reactions, potassium channels
pages: from 135 to 141
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