|M. Justyna Mierzejewska-Zawisza, Karina Jahnz-Różyk, Tadeusz Płusa|
Leukotrienes are potent proinflammatory agents and play important role in asthma. The involvement of leukotrienes in COPD as an inflammatory disease of respiratory tract is also suspected. The aim of this study was to compare urinary excretion of cysteinyl leukotrienes in asthma and in chronic obturative pulmonary disease and to reveal any correlation between leukotrienes urinary excretion and spirometry.
ELISA test was used to measure urinary cysteinyl leukotrienes and Master Lab by Jeager to perform spirometry in 16 patients from each group: mild to moderate persistent asthma, COPD (both stable) and healthy controls.
The mean FEV1 value (%) were 84.35±15 in asthma; 61.25±20.26 in COPD and 105.94±11.49 in control group. There was significant difference (p=0.012) between cysteinyl leukotrienes levels (pg/mg creatinine) in asthma patients (708.51±411.84; mean ±SD) and control group (407.76±300.75) and also between COPD patients (973.206 ±482.57) and control group (p=0.0002). Urinary excretion of cysteinyl leukotrienes correlated with FEV1 in COPD patients (r=-0.7).
Higher levels of urinary leukotrienes in COPD comparing to asthma prove that cysteinyl leukotrienes are important factors not only in the allergic inflammation. The results may provide evidence for application of antileukotriene drugs in COPD but controlled studies are required before any recommendations are made.
Alergia Astma Immunologia, 2001, 6(2), 101-104
keywords: leukotrieny cysteinylowe, obturacja oskrzeli, POChP, astma oskrzelowa, palenie papierosów, cysteinyl-leukotrienes, bronchoconstriction, COPD, asthma, smoking
pages: from 101 to 104
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