wersja polska  
Mediton - Publishing House
Start page  Journals  Books  Conferences  News  Mediton  Contact   
   Journals
print this
   Allergy Asthma Immunology - archive  

Allergy Asthma Immunology
     Archive
     Editorial staff
     Editorial board
     For authors
     Subscription
Otorhinolaryngology
Allergology Review



 Search in articles:
  Authority of Polish Society of Allergology




vol 6. no 2. June 2001  
 TABLE OF CONTENT

 Original articles
Urinary excretion of cysteinyl leukotrienes in bronchial asthma and chronic obstructive pulmonary disease
M. Justyna Mierzejewska-Zawisza, Karina Jahnz-Różyk, Tadeusz Płusa

Leukotrienes are potent proinflammatory agents and play important role in asthma. The involvement of leukotrienes in COPD as an inflammatory disease of respiratory tract is also suspected. The aim of this study was to compare urinary excretion of cysteinyl leukotrienes in asthma and in chronic obturative pulmonary disease and to reveal any correlation between leukotrienes urinary excretion and spirometry.
ELISA test was used to measure urinary cysteinyl leukotrienes and Master Lab by Jeager to perform spirometry in 16 patients from each group: mild to moderate persistent asthma, COPD (both stable) and healthy controls.
The mean FEV1 value (%) were 84.35±15 in asthma; 61.25±20.26 in COPD and 105.94±11.49 in control group. There was significant difference (p=0.012) between cysteinyl leukotrienes levels (pg/mg creatinine) in asthma patients (708.51±411.84; mean ±SD) and control group (407.76±300.75) and also between COPD patients (973.206 ±482.57) and control group (p=0.0002). Urinary excretion of cysteinyl leukotrienes correlated with FEV1 in COPD patients (r=-0.7).
Higher levels of urinary leukotrienes in COPD comparing to asthma prove that cysteinyl leukotrienes are important factors not only in the allergic inflammation. The results may provide evidence for application of antileukotriene drugs in COPD but controlled studies are required before any recommendations are made.
Alergia Astma Immunologia, 2001, 6(2), 101-104


keywords: leukotrieny cysteinylowe, obturacja oskrzeli, POChP, astma oskrzelowa, palenie papierosów, cysteinyl-leukotrienes, bronchoconstriction, COPD, asthma, smoking

pages: from 101 to 104



estimated time of download (91 kB)
broadband speed:561282565121024[kbps]
time:197422[sec]


You need to have Adobe Acrobat Reader to view the PDF file. It's free. If you don't have the Adobe Acrobat Reader plugin yet, you can get it HERE.


Start page | Journals | Books | Conferences | News | Mediton | Contact

Copyright © 1996-2020 Mediton Publishing House | All rights reserved.