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  Authority of Polish Society of Allergology

vol 6. no 2. June 2001  

 Original articles
The influence of budesonide on bone metabolism in children with asthma
Alina Puchnarewicz, Jolanta Tobolczyk, Marek Szczepański 2 , Danuta Rutkowska-Rogacz, Jerzy Hofman

The aim of study was to evaluate the influence of inhaled budesonide on selected parameters of bone metabolism (carboxyterminal propeptid of type I procollagen (PICP), carboxyterminal piridinoline crosslinked telopeptide of type I collagen (ICTP), and osteocalcin. The study included 25 children with chronic mild bronchial asthma (aged 4-17 years, mean: 11,2 years). Children were treated with inhaled budesonide at the dose of 1200µg/day for 14 days, then 800µg/day for 10 weeks, thereafter 400 µg/day for 3 months. Serum levels of PICP, ICTP were determined with radioimmunoassay (RIA, Orion Diagnostica). Osteocalcin was measured using a commercial OSTK-PR radioimmunoassay (Cis, Gif sur Yvette. France). Blood samples were collected after 3 and 6 months of treatment.
Osteocalcin (136.7±61.4µg/L) and PICP (459.4±161.5µg/L) concentrations were significantly decreased after 3 months of treatment in comparison with control group (150.8±49.1 and 497.2±123.0µg/L, respectively). Osteocalcin concentration significantly (p<0.001) decreased after 6 months in comparison with 3 months of treatment. ICTP did not change significantly.
Decreased PICP and osteocalcin concentration suggests the decreased rate of bone formation and might be clinically useful as a marker of early adverse effects of glucocorticoids on bone tissue.
Alergia Astma Immunologia, 2001, 6(2), 95-99

keywords: astma, budezonid, metabolizm kostny, dzieci, asthma, budesonide, bone metabolism, children

pages: from 95 to 99

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