wersja polska  
Mediton - Publishing House
Start page  Journals  Books  Conferences  News  Mediton  Contact   
   Journals
print this
   Allergy Asthma Immunology - archive  

Allergy Asthma Immunology
     Archive
     Editorial staff
     Editorial board
     For authors
     Subscription
Otorhinolaryngology
Allergology Review



 Search in articles:
  Authority of Polish Society of Allergology




vol 6. no 1. March 2001  
 TABLE OF CONTENT

 Original articles
Association between HLA-DRB1 polymorphism and markers of severity of rheumatoid arthritis
Marek L. Kowalski, Joanna Hilt, Joanna Stańczyk, Maciej Borowiec, Grzegorz Woszczek

It is now well established that genetic variations in HLA-DRB1 region may influence susceptibility to RA. The clinical manifestation of rheumatoid arthritis (RA) varies considerably among individual patients but genetic component of the disease severity has not been elucideted.
The goal of the study was to assess the association of the HLA-DRB1 gene with different markers of severity of the disease. Seventy six patients with RA and 152 healthy controls were typed for HLA-DRB1 gene by molecular method (Dynal RELI SSO HLA-DRB). Clinical, radiographic and immunological assessment of patients was conducted. DRB1*04 alleles were present in 47% of RA patients vs 25% of healthy controls (OR=2,7; pc=0,01). The frequency od DRB1*04 genes was higher in patiens with: rheumatoid factor (RF) positive RA (OR=14,9; pc=0,001), primarily chronic course of disease (OR=4,7; pc=0,03) and familial incidence of RA (OR=7,8; pc=0,02) comparing to RF-negative patients, with acute course of disease and without familial history of RA. DRB1*04 alleles were significantly more frequent in patients with more intensive joint destruction reflected by index (defined as the number of eroded joints/duration of the disease) ł1 (OR=12; pc=0,001). We did not observed differences in frequencies of DRB1*01 alleles neither between studied group and controls nor between subgroups of RA patients.
Our study confirmed association of DRB1*04 alleles not only with susceptibility to RA but with clinical features of the disease as well.
Alergia Astma Immunologia, 2001, 6(1), 51-56


keywords: reumatoidalne zapalenie stawów, genetyka, allele HLA-DR, rheumatoid arthritis, genetics, HLA-DR alleles

pages: from 51 to 56



estimated time of download (89 kB)
broadband speed:561282565121024[kbps]
time:197422[sec]


You need to have Adobe Acrobat Reader to view the PDF file. It's free. If you don't have the Adobe Acrobat Reader plugin yet, you can get it HERE.


Start page | Journals | Books | Conferences | News | Mediton | Contact

Copyright © 1996-2020 Mediton Publishing House | All rights reserved.