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  Authority of Polish Society of Allergology

vol 6. no 1. March 2001  

 Original articles
Side-effects of preseasonal immunotherapy with Pollinex®+ Rye in tree and grass pollen sensitive patients - a multicenter study
Marek L. Kowalski, Krzysztof Buczyłko, Dariusz Jurkiewicz, Piotr Kuna, Józef Małolepszy, Barbara Rogala, Barbara Majkowska-Wojciechowska

This study was aimed to analyze incidence of adverse symptoms in the course of preseasonal immunotherapy in patients allergic to tree or/and grass pollens. The preseasonal immunotherapy with Pollinex® and Pollinex®+Rye was studied in 1999 and it included 112 patients with tree and grass pollen allergy in seven out-patient allergy departments throughout Poland. "Large immediate local reactions", defined as the induration of more than 5 cm diameter in adults and 3 cm in children up to 13 yr. old were noted in 1.2% of injections. Minor reactions were observed in 12% and 3% after the first and sixth vaccine injection, respectively. Large delayed local reactions were found in 4.9% of total number of injections. The delayed "minimal" symptoms, (edema at injection site, pain and itching in forearm, rash at injection site, arm paresthesis) were noted by 19% of all patients between 2 and 24 hours after the vaccine administration. Late-onset systemic reactions were observed in 1.46% cases (including conjuctivitis, skin itching, sneezing, sense of general weakness and distortion, increased body temperature, headaches, painful joints, chest pains, disordered vision). The incidence of side-effects decreased along with subsequent injections. No significant changes of PEF measured prior to and an hour after the first six injections were found. However, the mean PEF measured after seventh injection was significantly decreased by 9 l (p < 0.01), even if none of the patients studied experienced dyspnea.
This study confirmed that Pollinex immunotherapy is a safe procedure involving minor number of mild side effects.
Alergia Astma Immunologia, 2001, 6(1), 45-50

keywords: immunoterapia swoista, objawy uboczne, pyłkowica, specific immunotherapy, side effects, pollenosis

pages: from 45 to 50

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