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  Authority of Polish Society of Allergology

vol 6. no 1. March 2001  

 Diagnostics and treatment of allergy
The mechanisms of specific immunotherapy
M. Jutel, J. Małolepszy

The mechanism of specific immunotherapy has been a subject of intense research and remarkable progress in recent years. It was found that immunotherapy may modify the specific immune response to restore its normal function in allergic patients. Functional modulation of allergen specific lymphocytes T is of essential role in evoking the clinical tolerance to allergens. The shift of specific cell T phenotype, from the dominant Th2 into Th1 type, is induced by IL-10 that brings about to cell anergy and subsequently, cell reactivation elicited by other cytokines. Moreover, large doses of an allergen may suppress specific Th2 lymphocytes and, therefore, favor Th1 dominance. Regarding that cytokines, released by respective lymphocyte populations, play essential role in the regulation of immunoglobulin synthesis and the activation of target cells, immunotherapy may decrease both humoral and cellular components of allergic inflammation.
Alergia Astma Immunologia, 2001, 6(1), 7-11

keywords: immunoterapia swoista, mechanizmy, limfocyty Th1 i Th2, cytokiny, immunoglobuliny, skuteczność kliniczna, specific immunotherapy, lymphocytes Th1 and Th2, cytokines, immunoglobulins, clinical effectiveness

pages: from 7 to 16

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