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  Authority of Polish Society of Allergology

vol 5. no 4. December 2000  

 Original articles
Allergen-specific IgE and IgG-4 to food allergens in patients with ulcerative colitis
Żak-Nejmark T., Małolepszy J., Wrzyszcz M., Jutel M., Nadobna G., Rączka A.

Immune response against common food allergens is considered to play a role in the pathogenesis of ulcerative colitis. Serum specific IgE and IgG4 levels against 8 common food allergens as well as skin prick tests (SPT) were performed in 16 patients with ulcerative colitis and 7 healthy controls. In some subjects from both groups serum specific IgE and IgG4 against food allergens and postive skin prick tests were found. The incidence of positive results and levels of serum specific IgE and IgG4 were similar in both groups. However positive SPT were clearly more often to be found and weal areas were generally larger in colitis patients. These results show that SPT, but not serum specific IgE and IgG4, might prove the involvement of specific immune response against common food allergens in the pathogenesis of ulcerative colitis.
Alergia Astma Immunologia, 2000, 5(4), 263-266

keywords: wrzodziejące zapalenie jelita grubego, etiopatogeneza, alergia pokarmowa, swoiste IgE, swoiste IgG-4, punktowe testy skórne, ulcerative colitis, etiopathogenesis, food allergy, specific IgE, specific IgG-4, prick tests

pages: from 263 to 266

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