|Barbara Rogala, Joanna Glück, Barbara Filipowska|
Atopic dermatitis (AD) is an allergic disease. Clinical significance of frequently diagnosed anaphylactic hypersensitivity to house dust mite allergens is the matter of controversy. The aim of the study was to assess clinical usefulness of atopy patch testing (ATP) with house dust mite allergens in the diagnosis of house dust mite sensitisation in patients with AD.
The results were analysed in the group of 15 patients and in two subgroups: the patients with intrinsic form of AD (wAZS) and the patients with documented anaphylactic hypersensitivity to house dust mites (aAZS). Skin prick tests and ATP with house dust mite allergens were performed in all subjects. Moreover, serum total and allergen-specific IgE was determined.
The strong correlation of skin prick test results, serum levels of allergen-specific IgE and ATP was found. ATP were positive in 9 subjects among 10 in aAZS group (90%). ATP were negative in entire wAZS group. The sensitivity and specificity of allergen-specific IgE assay as compared to ATP was 75% and 100%, respectively. The sensitivity and specificity of skin prick tests was 83%.
Therefore, ATP is a valuable diagnostic method of clinical significance estimation of house dust mite sensitisation in patients with AD. The positive ATP results point at the important role of delayed allergic reactions in AD immunopathophysiology.
Alergia Astma Immunol 2000; 5(2): 137-141
keywords: atopowe zapalenie skóry, roztocza kurzu domowego, atopowe testy płatkowe, atopic dermatitis, house dust mites, atopy patch tests
pages: from 137 to 141
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