|Marcin Krotkiewski, Kazimierz Madaliński|
The occurrence of atopic allergy becomes a significant problem in Western Europe and USA; Poland currently enters this dangerous zone. Environmental factors bring about to of this phenomenon (i.e. chemical and infectious agents, change of physiological bacterial flora). These factors are constantly changing along with the progression and improvement of social and hygienic conditions. We postulate that environmental factors stimulate the switch of Th1/Th2 lymphocyte balance into "proallergic" Th2 subpopulation, and consequently IFN-g/IL-4 balance into IL-4 prevalence. Thus, they are responsible for immunomodulation leading to development of allergy.
The increased level of hygiene eliminates lactic acid bacteria from digestive tract. This further may contribute to the prevalence of Th2 lymphocyte subpopulation. This view was supported by epidemiological studies comparing the occurrence of allergy in developed and developing countries. As stated in this paper, preliminary studies indicate that early probiotics introduction has immunomodulatory properties and may prevent the development of allergy.
Alergia Astma Immunol. 2000; 5: 1-6
keywords: alergia, czynniki środowiskowe, zakażenia, cytokiny Th1/Th2, probiotyki, allergy, environmental factors, infections, Th1/Th2 cytokines, probiotics
pages: from 1 to 6
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