|Barbara Rogala, Barbara Rymarczyk, Joanna Glück |
The genetical background of atopic diseases is an up?to?date problem for research. The unequivocal analysis of this phenomenon is difficult as the atopics differs phenotypically in a great manner.
The aim of the study was to analyse the occurrence of atopic features in parents of atopic offspring.
37 patients with allergic rhinitis, including 19 patients with seasonal allergic rhinitis and 18 patients with perennial allergic rhinitis and 74 their parents were enrolled into the study. All subjects underwent physical examination and the anamnestic data were collected. In all of them skin prick tests were performed and the estimation of serum concentration of total IgE, allergen specific IgE and IL?4 was done.
All the patients with allergic rhinitis showed elevated allergen specific IgE serum levels (>0.7 IU/ml). Total IgE serum levels were significantly higher in both examinated groups of offspring than in their parents. The occurrence of atopic features based on elevated total and allergen specific IgE serum levels was shown in 19% of parents ( 6 mothers and 8 fathers).
There were no statistically significant differences in IL?4 serum concentrations between the offspring and parent, or between both atopic groups. No correlation between total IgE and IL?4 serum concentrations in offspring and parent groups (r=0.09, r=0.05) was observed as well.
The low expression of atopy features in parents may be due to a recessive trait of inheritance and to a modulating influence of the environment onto the occurrence of atopic features.
keywords: atopia; alergiczny nieżyt nosa; dziedziczenie alergii, atopy; allergic rhinitis; heredity of atopy
pages: from 255 to 258
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