wersja polska  
Mediton - Publishing House
Start page  Journals  Books  Conferences  News  Mediton  Contact   
print this
   Allergy Asthma Immunology - archive  

Allergy Asthma Immunology
     Editorial staff
     Editorial board
     For authors
Allergology Review

 Search in articles:
  Authority of Polish Society of Allergology

vol 4. no 4. December 1999  

 Original articles
Atopy in parents of children with allergic rhinitis
Barbara Rogala, Barbara Rymarczyk, Joanna Glück

The genetical background of atopic diseases is an up?to?date problem for research. The unequivocal analysis of this phenomenon is difficult as the atopics differs phenotypically in a great manner.
The aim of the study was to analyse the occurrence of atopic features in parents of atopic offspring.
37 patients with allergic rhinitis, including 19 patients with seasonal allergic rhinitis and 18 patients with perennial allergic rhinitis and 74 their parents were enrolled into the study. All subjects underwent physical examination and the anamnestic data were collected. In all of them skin prick tests were performed and the estimation of serum concentration of total IgE, allergen specific IgE and IL?4 was done.
All the patients with allergic rhinitis showed elevated allergen specific IgE serum levels (>0.7 IU/ml). Total IgE serum levels were significantly higher in both examinated groups of offspring than in their parents. The occurrence of atopic features based on elevated total and allergen specific IgE serum levels was shown in 19% of parents ( 6 mothers and 8 fathers).
There were no statistically significant differences in IL?4 serum concentrations between the offspring and parent, or between both atopic groups. No correlation between total IgE and IL?4 serum concentrations in offspring and parent groups (r=0.09, r=0.05) was observed as well.
The low expression of atopy features in parents may be due to a recessive trait of inheritance and to a modulating influence of the environment onto the occurrence of atopic features.

keywords: atopia; alergiczny nieżyt nosa; dziedziczenie alergii, atopy; allergic rhinitis; heredity of atopy

pages: from 255 to 258

estimated time of download (74 kB)
broadband speed:561282565121024[kbps]

You need to have Adobe Acrobat Reader to view the PDF file. It's free. If you don't have the Adobe Acrobat Reader plugin yet, you can get it HERE.

Start page | Journals | Books | Conferences | News | Mediton | Contact

Copyright © 1996-2020 Mediton Publishing House | All rights reserved.