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Allergology Review

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  Authority of Polish Society of Allergology

vol 4. no 4. December 1999  

 Original articles
Food challenge testing in diagnostics of food allergy/intolerance in children

The aim of study was t evaluate the usefulness of oral food challenge tests in the diagnostics of food allergy and intolerance in children. The study involved 189 children (123 boys and 66 girls) aged 12 months - 14 years, with food hypersensitivity diagnosed basing on histor data, physical examination and allergological- immunological tests (IgEc, IgEs, prick-tests). Elimination diet was applied. To verify the preliminary diagnosis and determine the percentage of children who had already acquired tolerance to harmful food, all the children were subjected to oral foodload test - with open in 15.7% of the examined and with double-blind placebo controlled test in the remaining children. In 79 patients (41.8%) 109 (39,8%) positive results of provocation were found, mainly with cow milk (56.9%), egg white (15.6%) and fish (5.5%). The symptoms referred to skin (58.7%), alimentary tract (46.8%), the respiratory system (25.7%) and the central nervous system (2.7%). In 30 patients (27.5%) the reactions were immediate, in the remaining cases delayed (33.0%) and late (39.5%). False negative results constituted 3.6%. The results of the study indicate high usefulness of oral food challenge tests in diagnostics of food allergy and intolerance in children.

keywords: alergia pokarmowa, diagnostyka, podwójnie ślepa próba kontrolowana placebo, food allergy, diagnostics, double-blind placebo controlled test

pages: from 245 to 249

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