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  Authority of Polish Society of Allergology

vol 4. no 3. September 1999  

 Original articles
IgE-dependent immunological response in Helicobacter pylori positive patients with gastritis and food allergy
Zbigniew Bartuzi1, Bogdan Romański1, Jadwiga Korenkiewicz2, Magdalena Żbikowska-Gotz1, Jacek Gocki1

1)Katedra i Klinika Alergologii i Chorób Wewnętrznych AM, ul. Ujejskiego 75, 85-168 Bydgoszcz
2)Katedra i Zakład Patomorfologi Klinicznej AM w Bydgoszczy

Immunoglobulin E is the main antibody responsible for immediate type reactions. It can bind with FceRI receptors on mast cells and basophils including these in the alimentary tract. The aim of the study was to determine the presence of IgE binding cells in the gastric mucous and qualification concentrations W 4 in blood serum in patients with food allergy and H.pylori positive and negative chronic gastritis. 34 patients with food allergy and chronic gastrointestinal manifestations were studied. All patients underwent gastroscopy and had samples of the mucous membrane (from the antral region or body of the stomach) taken for histopathological evaluation for the levels of cellular infiltration and immunological assessment. Histopathology was carried out by the modified Giems method using hematoxilin and eosin stains. Immunological assessment was made by immunofluorescence technique using DACO preparations. The level of IL-4 in plasma was determined using ELISA. Histology confirmed gastritis in 32 cases. H. pylori was shown positive in 18 of the 32 samples. Infiltration of the gastric mucous by IgE-binding cells was found in 14 of the 18 H.pylori positive patients (78%) and in 7 of the 14 H.pylori negative patients (50%). There was a statistically significant difference between the levels of IgE binding cells in the gastric mucous from patients with food allergy and from patients with H.pylori positive gastritis and H.pylori negative gastritis. This may suggest the involvement of a type I hypersensitivity reaction in the development of chronic inflammatory disease of the stomach.
Alergia Astma Immunologia, 1999, 4(3), 183-189


pages: from 183 to 189

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