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  Authority of Polish Society of Allergology

vol 4. no 3. September 1999  

 Original articles
Individual dynamics of serum IgE levels in HIV-infected persons
Anna Muszyńska, Jerzy Kruszewski, Waldemar Halota1, Janusz Ślusarczyk2, Mirosław Kłos

The aim of this work was to assess individual dynamics of serum IgE levels (ssIgE) during HIV infection. The study was performed in 33 HIV-infected persons, during different stages of the infection. The absolute number of lymphocytes T CD4+ (CD4+) in peripheral blood (flow cytometry) and ssIgE (fluorometric method FAST IgE) were examined twice or three times at intervals of 18 months. The reference group consisted of 144 healthy blood donors who had ssIgE examined after the HIV infection had been ruled out. The analysis of individual dynamics of parameters showed that in HIV-infected persons together with the progression of the infection and with the increase in the quantity defect of CD4+ the increase of IgE synthesis occured. The less frequent occurrence of the increased ssIgE during the initial assessement in HIV-infected group suggests that persons with the increased ssIgE levels may be less susceptible to HIV infection as compared to subjects with lower levels of IgE.


pages: from 173 to 177

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