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  Authority of Polish Society of Allergology

vol 4. no 2. March 1999  

 Original articles
The influence of 4-week treatment with salmeterol on the concentration of soluble interlukine-2 receptor in the serum of asthmatic patients
Jolanta Wrońska, Ryszarda Chazan, Hanna Grubek-Jaworska, Joanna Mazurek, Wacław Droszcz

Katedra i Klinika Chorób Wewnętrznych iPneumonologii AM, ul. Banacha 1a, Warszawa

The aim of the study was to asses the influence of 4-week treatment with salmeterol on the concentration of soluble interleukin-2 receptor (sIL-2R) in serum of asthmatic patients. Twenty two asthmatic subjects (14 women, 8 men) in average age 34,7ą 11,2 were enrolled in the study. It was a double blind, placebo controlled trial. Salmeterol was given in inhalation 50ug twice a day. The concentration of sIL-2R in the serum was measured by Predicta Interleukin 2 Receptor Kit (Genzyme). Lung function tests (FEV1, FEV1%VC,PEF) were measured with the spirometer and hyperreactivity to histamine by standard bronchial provocation techniques. The concentration of sIL-2R in the serum decreased significantly p=0,03 after 4 weeks' treatment with salmeterol. In the placebo group there were no changes. The lung function tests did not improve during the observation in either groups.


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