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  Authority of Polish Society of Allergology

vol 4. no 1. January 1999  

 Clinical immunology
DNA vaccines - new aspects of specific immunotherapy for allergic diseases
Marcin Kurowski , Piotr Kuna

Klinika Pneumonologii i Alergologii AM w Łodzi, ul. Kopcińskiego 22, 90-153 Łódź

This paper is a review of an actual bibliography presenting the role of DNA immunization in allergic disease immunotherapy. Although the work on DNA vaccine application in allergies has not reached beyond the experimental phase so far, the results obtained up to now can be considered promising. Immunization with plasmid DNA containing allergen-encoding DNA inhibits production of IgE by means of e.g. IFN-a and IL-12 as well as suppresses the process of allergic inflammation. Questions concerning application safety of DNA vaccines and application procedures will be the subject of further studies.


pages: from 13 to 17

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