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Allergology Review

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  Authority of Polish Society of Allergology

vol 3. no 4. December 1998  

 Original articles
Oral provocation tests with synthetic food additives and aspirin in the diagnostic program of chronic urticaria
Michał Kurek1, Elżbieta Grubska-Suchanek2, Aleksandra Wilkowska2

1)Samodzielna Pracownia Alergologii Akademii Medycznej, ul. Dębinki 7, 80-211 Gdańsk
2)Klinika Dermatologii Akademii Medycznej w Gdańsku

Food additives and drugs are causal factors in 15 to 20% cases of chronic urticaria. Provocations tests can contribute to the diagnosis and elimination regime. The test consists of oral intake of selected additives and drugs given in progressive doses to a symptome-free subject following the principle of double blind, placebo controlled food challenge (DBPCFC) technique. We investigated 27 subjects with chronic urticaria and challenged 13 in the symptom-free period obtained after 7 - 14 days of an additive free and hypoallergenic diet regime. After challenge, urticaria clearly appear in 6 subjects. Tree tested persons were sensitive to both, natrium glutamate and aspirin. Two subjects were sensitive to aspirin or sodium benzoate only. In one case, urticaria symtoms were found after application of sodium benzoate, methyl-p-hydroxybenzoate, sodium bisulfite and monsodium glutamate. The causative role of food additives and aspirin in chronic utricaria can be evaluated according to the schedule based on DBPCFC principle.


pages: from 239 to 242

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