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  Authority of Polish Society of Allergology

vol 3. no 3. September 1998  

 Clinical immunology
Cytokines and basophiles - the role in the pathogenesis of bronchial asthma
Zofia Grzywacz, Piotr Kuna

Klinika Pneumonologii i Alergologii IMW Akademii Medycznej, ul. Kopcińskiego 22, 90-153 £ód¼

Since 1976 researches investigating "basophils releasability" have been conducted. We know today that several biochemical events, not only the surface density of IgE molecules, control the release of mediators from basophils of atopic persons in response to different activating stimuli. We connect these events with cytokines and their priming abilities. Investigations that have been made during last years indicate that late phase reaction is much more important in the pathogenesis of allergic diseases than the early asthmatic response. The main feature of LPR is eosinophils migration. However, other cells releasing cytokines like basophils, neutrophils and limfocytes T do it as well. We think, that basophils are not only the effector cells but mainly immunoregulatory cells that can contribute to development of atopic disease.


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