wersja polska  
Mediton - Publishing House
Start page  Journals  Books  Conferences  News  Mediton  Contact   
print this
   Allergy Asthma Immunology - archive  

Allergy Asthma Immunology
     Editorial staff
     Editorial board
     For authors
Allergology Review

 Search in articles:
  Authority of Polish Society of Allergology

vol 3. no 1. March 1998  

 Original articles
Comparison of the effects of muscarinic receptor antagonists M1 or M2 and M3 on exercised induced bronchoconstriction in asthmatic patients
Jerzy Liebhart, Anna Dor, Ewa Liebhart, Józef Małolepszy

Katedra i Klinika Chorób Wewnętrznych i Alergologii Akademia Medyczna, ul. Traugutta 57/59, 50-417 Wrocław

To asses the effects of muscarinic receptors on exercise induced bronchoconstriction an exercise provocation test at 80% of VO2 max was repeated 3 times in 14 patients with exercise induced asthma. The 2nd and 3rd challenges were conducted under double-blind conditions after 0,25 mg of ipratropium bromide (M2 and M3 antagonist) or 5 mg of pirenzepine (M1 receptor antagonist) given in nebulization. The test was considered as positive if a decrease in FEV1 by at least 15% of initial value was observed in any of consecutive spirometric measurements performed at 5, 10, 20 or 30 minutes after completing the exercise. All the results of the provocations conducted without pretreatment with anticholinergics were positive. After ipratropium bromide, the statistically significant reduction of exercise induced bronchoconstriction was found at 5, 10 and 20 min after exercise, while the effect of pirenzepine was small and statistically non significant.


pages: from 45 to 49

estimated time of download (75 kB)
broadband speed:561282565121024[kbps]

You need to have Adobe Acrobat Reader to view the PDF file. It's free. If you don't have the Adobe Acrobat Reader plugin yet, you can get it HERE.

Start page | Journals | Books | Conferences | News | Mediton | Contact

Copyright © 1996-2020 Mediton Publishing House | All rights reserved.