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  Authority of Polish Society of Allergology




vol 3. no 1. March 1998  
 TABLE OF CONTENT

 Original articles
Comparison of the effects of muscarinic receptor antagonists M1 or M2 and M3 on exercised induced bronchoconstriction in asthmatic patients
Jerzy Liebhart, Anna Dor, Ewa Liebhart, Józef Małolepszy

Katedra i Klinika Chorób Wewnętrznych i Alergologii Akademia Medyczna, ul. Traugutta 57/59, 50-417 Wrocław


To asses the effects of muscarinic receptors on exercise induced bronchoconstriction an exercise provocation test at 80% of VO2 max was repeated 3 times in 14 patients with exercise induced asthma. The 2nd and 3rd challenges were conducted under double-blind conditions after 0,25 mg of ipratropium bromide (M2 and M3 antagonist) or 5 mg of pirenzepine (M1 receptor antagonist) given in nebulization. The test was considered as positive if a decrease in FEV1 by at least 15% of initial value was observed in any of consecutive spirometric measurements performed at 5, 10, 20 or 30 minutes after completing the exercise. All the results of the provocations conducted without pretreatment with anticholinergics were positive. After ipratropium bromide, the statistically significant reduction of exercise induced bronchoconstriction was found at 5, 10 and 20 min after exercise, while the effect of pirenzepine was small and statistically non significant.

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pages: from 45 to 49



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