|Paweł Górski, Tomasz Wittczak|
Klinika Chorób Zawodowych Instytutu Medycyny Pracy, ul. św. Teresy od Dzieciątka Jezus 8, 90-950 Łódź
Chemokines, a special kind of cytokines, are essential for the directional migration of leukocytes during normal and inflammatory processes, expecially during allergic inflammation. Interleukin-8 and monocyte chemotactic and activating factor are the best-characterized members of the CXC and CC chemokine subfamilies, respectively. However about 30 human chemokines have been identified but are only partially characterized at the biological level. Chemokines are involved in chemotaxis and activation of monocytes, lymphocytes, neutropils, eosinophils, basophils and endothelial cells.
This review describes the chemokine subfamilies, the chemokine producer and target cells, their receptors and the role of chemokines during physiological and pathological conditions.
More and more evidence points to a role of chemokines in chemotaxis-related phenomena, such as the expression of adhesion molecules, the secretion of proteinases, hematopoesis and angiogenesis. Chemokines are also involved in diseases such as cancer, autoimmune diseases and bacterial or viral infection.
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