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  Authority of Polish Society of Allergology

vol 3. no 1. March 1998  

 Diagnostics and treatment of allergy
Pathogenetic mechanisms in allergic rhinitis - un update
James N. Baraniuk

Department of Medicine, Georgetown University, 3800 Reservoir Rd., Washington, DC 20007-2197

The latest concepts of pathogenesis of allergic rhinitis are presented in this article. Activation of Th2 lymphocytes by allergen results in the release of their characteristic combination of cytokines which promote mast cell proliferation and IgE production. Mast cell derived mediators and cytokines are responsible for cellular recruitment and developement of the late-phase response. Activation of eosinophils and release of their madiators contribute to development of mucosal hyperreactivity contributing to pathophysiology of allergic rhinitis.


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