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Allergology Review

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  Authority of Polish Society of Allergology

vol 20. no 2. June 2015  

 Original articles
A single system: two measurements of nitrogen oxide concentration in a nasal challenge test with an allergen
Edyta Krzych-Fałta, Bolesław Samoliński, Adam Sybilski, Oksana Wojas

Introduction. Due to its high sensitivity and specificity, nasal allergen
challenge (assessed using nitric oxide levels in exhaled air) occupies
a special place among differential diagnostic tests for allergic rhinitis.
Aim. The aim of this study was to assess the marker of inflammation
(nitric oxide) in exhaled breath condensate in nasal allergen challenge
(NAC) test.
Materials and methods. Sixty subjects were recruited for the study:
30 patients diagnosed with an allergy to common environmental allergens
and 30 healthy controls. The method applied in the study was
the NAC with the use of a standardised 5000 SBU/MI allergen dose,
monitored by measuring the concentration of nitric oxide in exhaled
air (from the nose (nNO) and the bronchi (oNO)).
Results. Measurements of the concentration of nitrogen oxide in the
air exhaled from the respiratory system showed a complexity of reactions
in the NAC, with clear differences between the group of subjects
with allergic rhinitis and the group of healthy controls. In the early
phase of the allergic reaction, nNO level decreased. At 4th hour after
nasal allergen application, oNO level increased from 22.17 to 23.13
ppb in the group of patients with allergic rhinitis. A moderate correlation
was found between the subjects’ complaints measured using
the VAS scale and: nNO before the NAC (r=0.569, p<0.05), at the
25th minute of the test (r=0.464, p<0.05) at the 4th hour of the test
(r=0.529, p<0.05) and oNO in the first test (r=0.295, p=0.022) at the
45th minute of the test (r=0.349, p=0.006) and in the late phase of
the allergic reaction (r=0.356, p<0.05).
Conclusion. NAC with measurements of nNO and oNO concentration
levels provide valuable information on the response of the respiratory
system to nasal challenge tests.

keywords: Donosowa Próba Prowokacyjna z Alergenem, poziom nNO i oNO,Nasal Allergen Challenge, level of nNO and oNO

pages: from 111 to 116

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