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Allergology Review

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  Authority of Polish Society of Allergology

vol 20. no 2. June 2015  

 Original articles
Tryptase and histamine in patients with angioedema due to C1-inhibitor deficiency (Hereditary Angioedema, HAE) and in patients with mastocytosis
Aleksander Obtułowicz, Magdalena Pirowska, Wojciech Dyga, Ewa Czarnobilska, Anna Wojas-Pelc

Introduction. Tryptase and histamine levels may serve as an indicator of
mast cells stimulation related to various diseases, such as mastocytosis,
IgE-related allergy, confirming their participation in the pathogenesis.
Aim. Analyse tryptase and histamine levels and assess the correlation between
tryptase and histamine levels in serum of the different groups of
study patients.
Material and methods. The determinations were performed in 14 mastocytotic
patients, including 6 patients with the systemic mastocytosis
and 8 with urticaria pigmentosa, in 14 with innate angio-motor oedema
due to C1 inhibitor deficiency, and in 10 healthy controls. Tryptase levels
were determined using PhadiaUniCAP TRYPTASE reagents. Histamine
concentrations were measured using HISTAMINE ELISA kit (LaborDiagnostikaNord).
Results. In 6 patients with systemic mastocytosis, the level of tryptase
was high (>60 μg/L). In the majority of the patients with urticaria pigmentosa,
the level of tryptase was elevated, but it did not exceed 60 μg/L.
In half of the patients with systemic urticaria, the level of histamine was
elevated, but it was not correlated with the increased level of tryptase.
In the people with hereditary angioedema due to C1 inhibitor deficiency,
the serum levels of tryptase and histamine were normal. In that group,
no correlation was shown to occur between the levels of the study parameters.
Conclusions. No correlation was found between tryptase and histamine
levels. Thus, it seems reasonable to conclude that the mediators are released
from the mast cells independently.

keywords: tryptaza, histamina, mastocytoza, dziedziczny obrzęk naczynioruchowy tryptase, histamine, mastocytosis, hereditary angioedema

pages: from 106 to 110

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