|Mateusz Łukaszyk, Ewelina Łukaszyk, Dorota Kozłowska, Maciej Klimek, Ziemowit Ziętkowski, Iwona Flisiak, Anna Bodzenta-Łukaszyk|
Introduction. Angioedema symptoms include subcutaneous and submucosal
edema, usually well demarcated, often asymmetric and most commonly
affecting the face, the upper respiratory and the gastrointestinal tract.
Aim. The aim of the study was to determine the prevalence and causes of
angioedema (AE), with and without urticarial, among patients hospitalized
in an university clinic.
Material and methods. We have analysed 705 medical records of patients
hospitalized between 2007-2014.
Results. It was shown that AE occurred more frequently in women without
than in those with urticaria (66.6% vs. 67.8%, respectively). The
average age of the hospitalized women was 48.7 years and men 50.8
years. Most of the patients were emergency – (62.1%) and 5.5% repeatedly-
hospitalized. Diagnostic hospitalizations (patients without clinical
symptoms) involved 37.9% of patients. Clinical symptoms of angioedema,
with or without urticaria, most often affected the face (87.2% vs.
92.7%), tongue (22.2% vs. 11.1%) and upper respiratory tract - shortness
of breath, coughing (21.4% vs. 18.1%). Etiological agent of edema
was determined in 54.1% of patients without urticaria and in 44.1% of
patients with urticaria. Angioedema without urticaria was due mostly
to non-steroidal anti-inflammatory drugs (NSAIDs), food, antibiotics and
insect stinging, while the angioedema with urticaria was usually caused
by NSAIDs, foods, antibiotics and cosmetics. Some co-morbidities were
also observed in both groups of patients, i.e., hypertension (45.6%
vs. 34.8%), thyroid diseases (14.4% vs. 20.1%), diabetes mellitus type
2 (9.2% vs. 4.9%).
Conclusions. Angioedema with and without urticaria was a frequent
cause of emergency hospitalization. Clinical symptoms most often affected
the face, tongue and upper respiratory tract. Etiology was explained
in approximately 50% of hospitalized patients. The most common concomitant
conditions included hypertension, thyroid disease, and type
keywords: obrzęk naczynioruchowy, pokrzywka, przyczyny, choroby współistniejące,angioedema, urticaria, causes, comorbidities
pages: from 101 to 105
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