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  Authority of Polish Society of Allergology

vol 20. no 2. June 2015  

 Review articles
Metabolism and the biological role of platelet-activating factor
Agnieszka Gęgotek, Elżbieta Skrzydlewska

Platelet-activating factor (PAF) is a glycerophospholipid which, as a signalling
molecule, is involved in many biological processes in both serum,
bone marrow, and in other body cells that have the ability to produce
and release it. PAF is a ligand of the transmembrane G-protein coupled
receptor, and its activation is responsible for many allergic reactions,
e.g., platelet activation, increased vascular permeability, or bronchospasm.
PAF has also a significant influence on the smooth muscles of
the stomach, the permeability of blood vessels in the kidney, and the
proper functioning of the female reproductive system. As PAF is able to
trigger the complete inflammatory process, the constant, highly specific
regulation of its level through its enzymatic breakdown catalysed by PAF
acetyl hydrolase that very selectively decomposes fatty acid derivatives
and thereby directly affects PAF levels to ensure systemic homeostasis
is also essential.

keywords: budowa PAF-u, synteza PAF-u, mechanizm działaniaPAF-u, regulacja poziomu PAF-u, mechanizm działania PAF-AH,PAF structure, PAF synthesis, mechanism of PAF activity, regulation of PAF level, mechanism of PAF-AH activity

pages: from 79 to 84

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