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Otorhinolaryngology
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  Authority of Polish Society of Allergology




vol 19. no 4. December 2014  
 TABLE OF CONTENT

 Original articles
CD25 molecule expression on peripheral blood CD4+ T cells in asthmatic patients
Andrzej Eljaszewicz, Małgorzata Rusak, Marta Jeznach, Paula Mikłasz,Milena Dąbrowska, Marcin Moniuszko, Anna Bodzenta-Łukaszyk

Introduction. Allergic inflammation underlying asthma is associated
with enhanced immune activation of numerous cell types localized in
lower airways, including T cells. To date, considerably less is known about
the levels of activation of circulating T cells in asthmatic patients. Similarly,
there is no data on the effects of glucocorticoids (GCS) on activation
of peripheral blood T cells in asthmatic patients. Recently, we have
demonstrated decreased levels of CD127 (interleukin-7 receptor; one of
T cell-associated activation markers) on circulating CD4+ T cells in asthmatic
patients.
Aim. Given these data, here we aimed to analyze expression levels of
another major activation marker, CD25 (interleukin-2 receptor), on peripheral
blood CD4+ T cells in asthmatic patients.
Material and Methods. We recruited 63 patients with mild, moderate
and severe asthma that were either treated or not treated with inhaled
GCS. The control group consisted of 13 healthy volunteers. All studied
subjects were assessed by flow cytometry for the expression levels of
CD25 on the surface of circulating CD4+ T cells.
Results. The levels of CD25 expression on circulating CD4+ T cells were
similar in healthy volunteers and patients with mild, moderate and severe
asthma, both untreated and treated with inhaled GCS. Similarly, 7-day
administration of oral GCS in patients experiencing asthma exacerbations
did not result in changes of CD25 expression on peripheral blood CD4+
T cells.
Conclusions. Altogether, our data indicate that neither allergic airway
inflammation nor GCS therapy directly affect CD25 expression on peripheral
blood CD4+ T cells of asthmatic patients.

keywords: astma, limfocyty T, CD25, glikokortykosteroidy, asthma, T cells, CD25, glucocorticoids

pages: from 251 to 255



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