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  Authority of Polish Society of Allergology

vol 19. no 4. December 2014  

 Review articles
Immunoglobulin substitution therapy
Ewelina Grywalska, Jacek Roliński

Preparations of immunoglobulin (Ig) are blood products produced from
plasma obtained from 1 000 to 15 000 healthy donors, often from different
countries. Ig contain a mixture of purified antibodies directed against
a variety of pathogens; therefore, they consist in almost 100% of class G
polyclonal immunoglobulins (IgG). Ig replacement therapy history dates
back to the 50’s of the XX century, when it has been shown that Ig administration
in patients with hypogammaglobulinemia and disorders of
the functions and the stock of CD19+ B lymphocytes leads to a reduction
of infections.
Nowadays, a rapid increase in interest in the use of intravenous Ig (IVIG)
or subcutaneous Ig (SCIG) is observed in the treatment of many diseases
handled by immunologists, hematologists, neurologists, nephrologists,
rheumatologists and dermatologists. Replacement therapy is extensively
used in the treatment of both primary (i.a. common variable immunodeficiency,
X-linked agammaglobulinemia, hyper-IgM syndromes, severe
combined immunodeficiency) and secondary (i.a. in the course of chronic
lymphocytic leukemia, multiple myeloma, the state after the hematopoietic
stem cell transplantation) immunodeficiency syndromes.
In this paper, we have reviewed indications for immunoglobulin replacement
therapy, side effects of immunoglobulin preparations registered in
Poland, as well as the standards of Ig administration.

keywords: immunoglobuliny do podawania dożylnego, immunoglobuliny do podawania podskórnego, pierwotne niedobory przeciwciał,wtórne niedobory przeciwciał, terapia substytucyjna , intravenous immune globulin, subcutaneous immune globulin, primary antibody deficienci

pages: from 210 to 223

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