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  Authority of Polish Society of Allergology

vol 19. no 4. December 2014  

 Review articles
Humoral immunodeficiencies in adults
Magdalena Celińska-Löwenhoff, Jacek Musiał

The most common humoral immunodeficiencies, that constitute 65% of
primary immunodeficiency disorders, comprise selective IgA deficiency,
common variable immunodeficiency, X-linked agammaglobulinemia, IgG
subclass deficiency, specific antibody deficiency, hyper-IgE syndrome and
hyper-IgM syndromes. Because most of these syndromes are rare, the
diagnostic delay may be as long as several years, and some of them are
diagnosed in adults. On the other hand, a better patient care, intensive
modern antibiotic therapy and, most of all, immunoglobulin substitution
have improved patients’ survival, allowing them to achieve adulthood,
when they become the internal medicine patients. The authors present
the pathogenesis, symptomatology and treatment regimens of the most
common humoral immunodeficiencies in adults, focusing on differences
in manifestations, especially autoimmune symptoms and increased malignancy

keywords: niedobór odporności humoralnej, immunoglobuliny,nawracające zakażenia, objawy autoimmunologiczne,humoral immunodeficiency, immunoglobulins, recurrent infections, autoimmune symptoms

pages: from 202 to 209

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