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Otorhinolaryngology
Allergology Review



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  Authority of Polish Society of Allergology




vol 19. no 3. September 2014  
 TABLE OF CONTENT

 Original articles
Is elevated basal serum tryptase level a risk factor for Hymenoptera post sting severe anaphylactic reaction?
Bartosz Olędzki, Ziemowit Ziętkowski, Jacek Jamiołkowski,Andrzej Szpak, Anna Bodzenta-Łukaszyk

Introduction. Among individuals allergic to Hymenoptera venom, the
severity of post sting anaphylactic response may be associated with
a number of risk factors. A relationship between serum basal tryptase
level and anaphylactic reaction was shown recently in adults with venom
allergy.
Aim. The aim of this study was to answer the question whether elevated
serum tryptase concentration is the risk factor of severe post sting anaphylactic
reaction.
Materials and methods. The study involved the medical records of patients
with a history of severe post sting systemic reaction (IV degree of
H.L. Mueller scale), which were compared with the records for a group of
individuals with mild post sting reaction (II degree of H.L. Mueller scale).
The basal serum tryptase levels were determined and compared. All laboratory
testing was carried out at least 8-18 weeks since the last stinging.
Results. Elevated level of basal serum tryptase was observed among patients
who suffered severe systemic reactions of IV degree (according to
H.L. Mueller scale) in comparison to those recorded in the group of patients
with mild (II degree) systemic reaction (11.274 ng/ml vs. 3.569 ng/
ml, p<0.05).
Conclusion. Elevated level of basal serum tryptase is a significant risk
factor for the development of severe post sting reaction.

keywords: alergia na jad owadów błonkoskrzydłych, tryptaza, anafilaksja,Hymenoptera venom allergy, tryptase, anaphylaxis

pages: from 170 to 173



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