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  Authority of Polish Society of Allergology

vol 19. no 3. September 2014  

 Review articles
Current insights on exercise-induced bronchoconstriction pathogenesis in asthmatic patients
Ziemowit Ziętkowski, Mateusz Łukaszyk, Elżbieta Ziętkowska, Anna Bodzenta-Łukaszyk

Cough, wheezing and dyspnea followed by physical activity are the syndromes
as well as control parameters typical of asthma. Strenuous exercise
evokes a decrease in temperature of the air passing through lower
airways, desiccating the airway’s mucus membrane and increasing it’s
osmolarity leading to mast cells degranulation, mediator release, bronchial
smooth muscles constriction and epithelium damage. The latest
data confirms the indubitable correlation between the ongoing inflammatory
process characteristic of asthma and the airway epithelium, platelet
activation and an increase in pro-inflammatory mediator expression,
which should determine the therapeutic proceedings.

keywords: powysiłkowy skurcz oskrzeli, astma, patogeneza, wysiłek,exercise induced bronchoconstriction, asthma, pathogenesis, exercise

pages: from 126 to 129

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