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  Authority of Polish Society of Allergology

vol 18. no 4. December 2013  

 Review articles
Mast cell activation syndrome and monoclonal mast cell activation syndrome –the importance of the diagnosis among patients with anaphylaxis
Marek Niedoszytko, Marta Gruchała-Niedoszytko

The increased incidence of anaphylaxis is reported in the epidemiological data. In some patients the anaphylactic reaction is caused by the increased number of monoclonal mast cell. the mast cell activation syndrome can be diagnosed in subjects presenting symptoms of mast cell degranulation with subsequent response to antihistamine treatment and increased tryptase level during the reaction,. The mast cell activation syndromes are classified into following three types 1. primary, 2. secondary (found i.e. In allergic diseases), 3. idiopathic. The pathological examination may reveal the diagnosis of mastocytosis or, when only 2 minor criteria are met - the monoclonal mast cell activation syndrome. The treatment of patients with monoclonal mast cell activation syndrome is similar to patients suffering from indolent systemic mastocytosis.

keywords: mastocytoza, anafilaksja, mastocyty, mastocytosis, anaphylaxis, mast cells

pages: from 209 to 212

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