|Adam Jerzy Sybilski, Filip Raciborski, Agnieszka Lipiec, Aneta Tomaszewska, Adam Lusawa, Piotr Samel-Kowalik, Artur Walkiewicz, Edyta Krzych,Jarosław Komorowski, Bolesław Samoliński |
Introduction. Data on the importance of sensitization in atopic dermatitis (AD) is controversial. It is the question which AD is atopic disease.
Aim. To analyze the impact of sensitization to aeroallergens in AD. Is there a similar pattern of sensitization in patients with AD, allergic rhinitis (AR) and asthma?
Material and methods. We studied 4783 participants (29.46% 6-7 yo, 27.98% 13-14 yo, 22.73% adults) in 8 urban and 1 rural area. Allergologist diagnosed AD based on Hanifin-Rajka’s criteria. Skin prick tests (SPT) was performed with the 15 most common aeroallergens. SPT was positive when the wheal was 3 - 5 mm, remarkable positive ≥ 6 mm.
Results. AD was diagnosed in 6.5% of patients, asthma in 10.6%, AR in 28.9%. A positive SPT to at least one aeroallergen was in 45.8% (6-7 yrs 39.3% 48.6% 13-14 years of age, adults 48.2%). The most sensitizing were D. pteronyssinus (24.7%), D. farinea (21.6%) and grass/grain (22.3%). SPT was positive in 66.9% of patients with AD, 84.63% AR, 70.5% asthma. In patients with AD the most sensitizing were D. pteronyssinus (33.1%), D. farinea (33.2%) and grass/grain (30.6%). Sensitization to Cladosporium (OR 2.03), D. farinea (OR 2.0), cat (OR 2.01) and birch (OR 1.98) had the greatest impact on AD.
Conclusions. We confirmed the high prevalence of sensitization to aeroallergens in patients with AD, although less than in AR and asthma. Sensitization to aeroallergens was a risk factor for AD. In the general population the greatest impact on the presence of AD was sensitization to Cladosporium, D. farinea, cat and birch.
keywords: atopowe zapalenie skóry, uczulenie, aeroalergeny, czynniki ryzyka,atopic dermatitis, sensitization, aeroallergens, risk factors
pages: from 182 to 187
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