|Aleksandra Szczawińska-Popłonyk, Husam Samara, Anna Bręborowicz,Grzegorz Dworacki, Lidia Ossowska, Agata Kolecka-Bednarczyk |
Introduction. Antibody biosynthesis defects are the most prevalent category of primary immune deficiencies of diverse immunopathology, clinical manifestation and genetic background. In numerous disorders of antibody production, defects of B lymph cells differentiation and maturation have been well recognized. However, the role of T lymph cells in the pathomechanism of hypogammaglobulinemia in infants and young children has not been elucidated.
Aim of the study. The purpose of the study was examination whether deficiencies of antibody production in infants and young children are associated with disturbancies of expression of the selected surface markers on T lymph cell subsets. These informations could contribute to better understanding of the pathomechanism of hypogammaglobulinemia.
Materials and methods. Twenty-two children, aged from 8 to 61 months in whom deficiency of one or more immunoglobulin isotype was revealed, were included in the study. Immunophenotypic evaluation of peripheral blood T lymph cells maturation was conducted by flow cytometry. The identified surface markers were CD45, CD3, CD4, CD8, HLA-DR, CD45RA and CD45RO.
Results. Characteristic immunophenotype included the increased proportion of functionally immature CD3+CD4-CD8- lymph cell population as well as increased expression of T lymph cell activation markers – HLA-DR and CD45RO.
Conclusions. Antibody biosynthesis defects in infants and young children are not exclusively confined to hypogammaglobulinemia, but they also comprise a spectrum of disorders of cellular elements of the immune system.
keywords: hipogammaglobulinemia, limfocyty T, immunofenotyp, dzieci, hypogammaglobulinemia, T lymphocytes, immunophenotype, children
pages: from 175 to 181
|estimated time of download (716 kB)|